TABLE 2

Estimates of the average coefficient of dominance (± standard error) for a model where hN follows a beta distribution with mean Embedded Image or 0.2, and variance Embedded Image or 0.02, respectively, and values are uncorrelated with s

Methodλ = 0.2, = 0.02,
 β = 2λ = 0.2, = 0.02,
 β = 1.01λ = 0.006, = 0.2,
 β = 1.01λ = 0.006, = 0.2,
 β = 1.01
N0.4 0.4 0.4 0.2
Embedded ImageSIM 1030.32 ± 0.0030.34 ± 0.0020.31 ± 0.0240.14 ± 0.013
DA 1030.32 ± 0.0040.35 ± 0.0030.32 ± 0.0070.15 ± 0.004
DA 1050.27 ± 0.0040.31 ± 0.0140.26 ± 0.0110.13 ± 0.013
DA 1070.25 ± 0.0040.30 ± 0.0220.30 ± 0.0220.09 ± 0.006
N(1/s)0.250.250.250.07
by.xSIM 1030.32 ± 0.004 (0.32)0.31 ± 0.001 (0.31)0.23 ± 0.022 (0.25)0.10 ± 0.005 (0.11)
DA 1030.31 ± 0.003 (0.31)0.31 ± 0.004 (0.31)0.24 ± 0.003 (0.26)0.10 ± 0.004 (0.12)
DA 1050.26 ± 0.003 (0.26)0.25 ± 0.007 (0.26)0.21 ± 0.007 (0.23)0.06 ± 0.003 (0.08)
DA 1070.25 ± 0.005 (0.25)0.25 ± 0.006 (0.25)0.21 ± 0.004 (0.22)0.06 ± 0.002 (0.07)
N(s)0.250.250.250.07
Embedded ImageSIM 1030.36 ± 0.0020.36 ± 0.0010.27 ± 0.0150.13 ± 0.006
DA 1030.35 ± 0.0010.36 ± 0.0010.28 ± 0.0030.13 ± 0.002
DA 1050.31 ± 0.0010.31 ± 0.0010.25 ± 0.0040.09 ± 0.002
DA 1070.30 ± 0.0030.30 ± 0.0040.25 ± 0.0040.07 ± 0.001
N0.250.250.250.07
1/bx.ySIM 1030.43 ± 0.002 (0.44)0.43 ± 0.004 (0.44)0.33 ± 0.013 (0.36)0.21 ± 0.009 (0.25)
DA 1030.43 ± 0.001 (0.44)0.43 ± 0.002 (0.44)0.34 ± 0.003 (0.36)0.21 ± 0.003 (0.24)
DA 1050.40 ± 0.002 (0.47)0.40 ± 0.003 (0.47)0.32 ± 0.004 (0.35)0.15 ± 0.003 (0.18)
DA 1070.40 ± 0.002 (0.52)0.40 ± 0.004 (0.51)0.32 ± 0.003 (0.35)0.15 ± 0.002 (0.18)
NEmbedded Image0.400.400.400.20
  • DA 10n, diffusion approximation for a population of size N = 10n; SIM 103, simulation results for a population of size N = 103; MSB predictions (in italics) are analytically derived expectations. λ, haploid mutation rate per chromosome and generation; , mean homozygous mutational effect; β, shape parameter for the gamma distribution of mutational effects. Values in parentheses correspond to estimates from quasi-normal chromosomes.