TABLE 4

Mutational statistics from regression analyses

Experiment 1Experiment 2Experiment 3
Mutational statistics
 for the
 quasi-normal linesAll nonlethalsMutational statistics
 for the
 quasi-normal linesAll nonlethalsMutational statistics
 for the
 quasi-normal linesAll nonlethals
bM (×103)−2.08 ± 1.77−4.88 ± 1.87−5.68 ± 0.857−7.65 ± 0.873 −4.01 ± 1.20−3.79 ± 1.44
bC (×103)−4.12 ± 5.19−5.33 ± 1.62−0.730 ± 2.45
DM (×103)1.06 (−2.15/4.48)2.86 (0.10/9.72)6.66 (5.16/8.25)8.42 (6.42/10.5)3.75 (1.60/6.43) 3.27 (0.89/6.35)
u* (×102)0.25 (−0.88/3.45)2.86 (−1.57/12.2)24.1 (10.9/44.6)8.12 (4.68/12.4)5.89 (−0.34/16.7)11.2 (−2.01/37.8)
s*−1.27 (−3.56/−0.181)0.205 (−0.022/0.764)0.023 (0.010/0.035)0.100 (0.069/0.133)0.064 (0.021/0.165) 0.064 (−0.003/0.215)
  • bM and bC are the regression coefficients on assay generation (with standard errors) of the genotypic means and control means for each generation, respectively. The estimates of DM, u*, and s* (after normalizing the data by the mean control genotypic values) are the means over 1000 bootstrap replicates, with corrections for bias.