TABLE 4

Summary of meiotic DNA breakage and repair in S. pombe mutants studied here and in related S. cerevisiae mutants

S. pombeS. cerevisiae
MutantBreakageRepairMutantBreakageRepair
rad50+rad50
rad32+mre11
rhp51+rad51+
dmc1++dmc1a++ or −
swi5+sae3+
rad22 rti1+brad52+
mus81+mus81++
mei4cNAndt80d+
  • a dmc1 mutations have a more severe phenotype in derivatives of strain SK1 than in derivatives of another strain (see discussion).

  • b Repair at low level occurs in the rad22 rti1 mutant (see discussion).

  • c The S. pombe Mei4 protein is not a homolog of the S. cerevisiae Mei4 protein.

  • d Ndt80 is not structurally related to Mei4 (see discussion), nor is there evidence for homology between these proteins.

  • +, breakage or repair occurs in the indicated mutant; −, breakage or repair does not occur or is significantly reduced. NA, not applicable, because repair has not been assessed in the absence of normal breakage.