TABLE 4

Influence of mutations involved in PRR on the forward mutation rate of mph1 mutants to canavanine resistance

StrainMutation rate × 107Relative rateStrainMutation rate × 107Relative rate
Wild type2.4 ± 0.3911rad55.1 ± 0.8912.1
3.8 ± 0.5329.8 ± 1.222.6
3.0 ± 0.4135.1 ± 0.7731.7
mph127.0 ± 3.3111.3rad5 mph110.8 ± 1.614.5
35.1 ± 4.229.217.6 ± 2.124.6
21.8 ± 2.437.310.6 ± 1.333.5
rad67.1 ± 1.113.0ubc1314.8 ± 1.816.2
rad6 mph12.6 ± 0.4511.115.9 ± 1.824.2
rad1811.8 ± 1.714.9ubc13 mph121.4 ± 2.618.9
rad18 mph16.7 ± 0.9512.835.8 ± 3.929.4
rev11.1 ± 0.2730.37mms216.1 ± 2.216.7
rev1 mph16.4 ± 0.8132.1mms2 mph137.6 ± 4.4115.7
  • Relative rates were calculated by normalizing mutant mutation rates to the wild-type rate determined in that particular experiment, which is indicated by the indices 1–3. The errors indicated are the quotients of the standard deviations of the number of mutations (Lea and Coulson 1948) and total cell numbers.