TABLE 4

Reported genetic interactions with SSD1-V

GeneFunctionGenetic interactionReference
ARL1Membrane traffickingtsRosenwald et al. (2002)
BCK1Protein kinase involved in cell-wall integrityts, otherCostigan et al. (1992)
BEM2GTPase-activating protein required for polarized cell growthtsKim et al. (1994)
BUL1Protein that binds ubiquitin ligasetsYashiroda et al. (1996)
CBK1Protein kinase involved in cell morphogenesisDu and Novick (2002)
CBC2Component of cap-binding complexsl(sto1)Fortes et al. (1999)
CCR4Transcriptional regulator of glucose-repressed and cell-wall genessl(mpt5), tsKaeberlein and Guarente (2002)
CDC28Cyclin-dependent protein kinasetsSutton et al. (1991)
CET1mRNA capping enzymetsVincent et al. (2003)
CLN1, CLN2G1 cyclinsGCvrckova and Nasmyth (1993)
CYR1Adenylate cyclasetsM. Kaeberlein and L. Guarente, unpublished results
DHH1ATP-dependent RNA helicasesl(elm1)Moriya and Isono (1999)
ELM1Serine/threonine protein kinase that regulates pseudohyphal growthsl(dhh1)Moriya and Isono (1999)
HDF1Component of DNA end-joining repair pathwaytsM. Kaeberlein and L. Guarente, unpublished results
JNM1Protein required for proper nuclear migration during mitosistsWilson et al. (1991)
LAS1Essential gene required for bud formation and morphogenesistsDoseff and Arndt (1995)
LUV1Protein involved in protein sorting in the late Golgisl(rbl2)Smith et al. (1998)
MEP1, MEP2Ammonium permeases involved in regulating pseudohyphal growthGLorenz and Heitman (1998)
MPT5Protein required for high temperature growth and normal life spants, sl(ccr4, swi4, swi6)Kaeberlein and Guarente (2002)
PAG1Protein that functions with Cbk1p to regulate cell morphogenesisDDu and Novick (2002)
PDE23′,5′-cyclic-nucleotide phosphodiesteraseMiscellaneousWilson et al. (1991)
PPH21, PPH22Catalytic subunits of protein phosphatase 2Ats, otherEvans and Stark (1997)
PRP18U5 snRNA-associated proteintsLuukkonen and Seraphin (1999)
PRP22Pre-mRNA splicing factortsVincent et al. (2003)
RBL2Putative tubulin cofactor Asl(luv1)Smith et al. (1998)
RDS3Spliceosome componenttsVincent et al. (2003)
RLM1Transcription factor downstream of MPK1tsWatanabe et al. (1995)
RPC31RNA polymerase IIItsStettler et al. (1993)
RPC53RNA polymerase IIIStettler et al. (1993)
RPD3Histone deacetylase component of the Rpd3p-Sin3p complexsl(swi6)Vannier et al. (2001)
RPT4Proteosome ATPasetsMcDonald et al. (2002)
RRD1Phosphotyrosyl phosphatase activatorsl(rrd2)Rempola et al. (2000)
RRD2Protein involved in rapamycin sensitivitysl(rrd1)Rempola et al. (2000)
SDS3Component of the Rpd3p-Sin3p histone deacetylase complexsl(swi6)Vannier et al. (2001)
SIN3Component of the Rpd3p-Sin3p histone deacetylase complexsl(swi6)Vannier et al. (2001)
SIT4Phosphatase required for G1-S transitionLSutton et al. (1991)
SLC5UnknowntsVincent et al. (2003)
SLG1Protein required for maintenance of cell-wall integritytsJacoby et al. (1998)
SLT2MAP kinase that functions downstream of BCK1/SLK1tsMartin et al. (1996)
SLY1Protein involved in vesicle traffickingtsKosodo et al. (2001)
SMC2Subunit of condensin protein complextsStrunnikov et al. (2001)
SMC4Subunit of condensin protein complextsStrunnikov et al. (2001)
SNP1U1 snRNA-associated proteintsLuukkonen and Seraphin (1999)
STO1Component of cap-binding complexsl(cbc2)Fortes et al. (1999)
SWI4Cell-cycle-specific transcription factorts, sl(mpt5)Kaeberlein and Guarente (2002)
SWI6Cell-cycle-specific transcription factorts, sl(mpt5)Kaeberlein and Guarente (2002)
U5AIU5 snRNAtsLuukkonen and Seraphin (1999)
YPT1GTP-binding protein involved in the secretory pathwaytsLi and Warner (1998)
YPT6GTP-binding protein involved in the secretory pathwaytsLi and Warner (1998)
  • Reported effects of addition of SSD1-V are shown. ts, suppresses temperature sensitivity; sl (x), suppresses synthetic lethality between given gene and gene x; G, improves growth; L, suppresses lethality; D, causes death.