TABLE 2

Overlap in gene expression profiles with CR

Life-span-extending
mutation/intervention
No. of genes
differentially transcribed
Overlap with CRP value
SSD1-V9760.01
HAP4 overexpression25555<10–30
High osmolarity11748<10–30
Calorie restriction124124
  • Microarray analysis was performed on logarithmically growing cells in YPD for each of the long-lived cell types listed. The P value was calculated using a hypergeometric distribution and represents the probability that the number of genes similarly regulated by two life-span-extending interventions would be observed by chance. All microarray data sets are available at http://web.mit.edu/biology/guarente/arrays/kaeberlein (see materials and methods).