TABLE 2

MLEs of allelic action and interaction effects for a QTL bracketed by two flanking markers Embedded Image and Embedded Image under different sample sizes (n) and heritability (H2) levels

n = 200n = 400n = 800
ParameterH2 = 0.2H2 = 0.4H2 = 0.2H2 = 0.4H2 = 0.2H2 = 0.4
r1 = 0.100.10(0.04)0.10(0.03)0.11(0.04)0.10(0.02)0.10(0.02)0.10(0.01)
σ2 = 3.45/1.292.37(1.16)0.88(0.45)2.97(0.53)1.11(0.21)3.20(0.32)1.19(0.12)
Embedded Image 0.87(0.34)0.87(0.20)0.92(0.22)0.92(0.13)0.93(0.12)0.93(0.09)
Embedded Image 0.34(0.29)0.33(0.21)0.36(0.18)0.30(0.13)0.31(0.13)0.33(0.08)
Embedded Image –0.30(0.32)–0.35(0.18)–0.39(0.23)–0.35(0.13)–0.37(0.13)–0.35(0.09)
Embedded Image 0.76(0.32)0.77(0.21)0.79(0.20)0.79(0.12)0.84(0.12)0.85(0.07)
Embedded Image 0.23(0.34)0.26(0.21)0.27(0.20)0.29(0.15)0.30(0.15)0.32(0.09)
Embedded Image –0.18(0.39)–0.24(0.20)–0.27(0.19)–0.28(0.12)–0.29(0.11)–0.31(0.08)
Embedded Image –0.08(0.31)–0.05(0.21)–0.08(0.19)–0.07(0.22)–0.08(0.15)–0.09(0.08)
Embedded Image –0.14(0.26)–0.11(0.18)–0.11(0.16)–0.15(0.15)–0.12(0.12)–0.12(0.07)
Embedded Image 0.20(0.33)0.20(0.21)0.20(0.21)0.22(0.18)0.21(0.15)0.19(0.08)
Embedded Image –0.00(0.28)–0.02(0.16)–0.02(0.17)0.03(0.13)–0.00(0.11)–0.01(0.07)
Embedded Image 0.15(0.58)0.14(0.29)0.14(0.36)0.05(0.21)0.09(0.18)0.10(0.15)
Embedded Image 0.04(0.54)–0.00(0.29)–0.08(0.33)–0.05(0.21)–0.07(0.22)–0.01(0.15)
Embedded Image 0.02(0.55)–0.01(0.31)0.13(0.35)0.10(0.23)0.16(0.26)0.05(0.14)
Embedded Image –0.05(0.34)0.02(0.29)–0.03(0.30)0.01(0.22)–0.03(0.26)0.00(0.14)
Embedded Image –0.02(0.39)–0.03(0.31)–0.14(0.39)0.01(0.22)–0.10(0.22)–0.03(0.14)
Embedded Image –0.18(0.40)–0.02(0.33)0.08(0.36)–0.02(0.21)0.03(0.24)–0.02(0.15)
Embedded Image 0.18(0.46)0.15(0.32)0.16(0.35)0.20(0.23)0.18(0.20)0.19(0.15)
Embedded Image 0.00(0.53)–0.04(0.33)0.05(0.38)–0.01(0.23)0.07(0.23)–0.01(0.14)
Embedded Image –0.04(0.51)–0.02(0.36)–0.15(0.35)–0.12(0.23)–0.15(0.23)–0.09(0.16)
Embedded Image 0.09(0.47)0.04(0.38)0.14(0.39)0.07(0.25)0.20(0.27)0.18(0.14)
Embedded Image 0.19(0.57)0.07(0.32)0.07(0.39)0.10(0.25)0.17(0.25)0.16(0.16)
Embedded Image 0.05(0.56)0.14(0.33)0.09(0.38)0.12(0.26)–0.01(0.26)0.03(0.16)
Embedded Image –0.17(0.40)–0.11(0.34)–0.21(0.30)–0.14(0.22)–0.21(0.20)–0.24(0.13)
Embedded Image –0.14(0.36)–0.09(0.28)–0.13(0.33)–0.12(0.20)–0.13(0.22)–0.14(0.14)
Embedded Image –0.08(0.54)–0.09(0.32)–0.04(0.38)–0.07(0.21)–0.02(0.22)–0.01(0.15)
Embedded Image 0.05(0.37)–0.11(0.35)0.08(0.39)–0.04(0.25)–0.01(0.26)–0.01(0.15)
Embedded Image –0.08(0.51)–0.01(0.37)0.08(0.38)–0.08(0.23)–0.04(0.29)–0.01(0.15)
Embedded Image 0.09(0.59)–0.02(0.33)–0.10(0.41)0.06(0.24)0.01(0.25)–0.01(0.16)
Embedded Image –0.06(0.52)0.04(0.31)–0.05(0.29)0.04(0.18)0.01(0.20)–0.00(0.14)
Embedded Image –0.09(0.48)0.02(0.31)–0.05(0.25)0.04(0.20)0.03(0.22)0.01(0.13)
Embedded Image –0.04(0.47)–0.05(0.35)–0.01(0.35)–0.05(0.16)–0.04(0.21)–0.01(0.13)
δ1212 = –0.09–0.07(0.48)–0.06(0.38)–0.04(0.33)–0.07(0.35)–0.06(0.30)–0.10(0.16)
δ1213 = –0.010.08(0.48)–0.06(0.37)–0.09(0.37)0.01(0.25)0.01(0.23)–0.01(0.15)
δ1312 = 0.030.05(0.48)0.08(0.33)–0.05(0.33)0.02(0.22)0.05(0.24)0.03(0.12)
δ1313 = 0.03–0.08(0.43)–0.00(0.27)0.07(0.30)0.03(0.18)–0.01(0.17)0.02(0.11)

The numbers given in the first column (parameter) are the hypothesized values for these QTL parameters. The symbols for QTL effects are given in the text and in appendix a. The standard errors of the MLEs are estimated from 100 simulations and are given in parentheses.