TABLE 1

Results of fitting multi-epoch models of allele frequency spectrum to population-specific observed allele frequency data

Model structureModel parametersResulting pairwise θ (units of 10–4)ln P(data|model)Improvement over lower-epoch model
a. European data
One epochN1 = 10,0008.00–55.98
Two epochN2 = 10,0008.74–38.112 ln λ = 35.74
N1 = 140,000P < 10–4
(T1 = 2,000)Highly significant
Three epochN3 = 10,0007.88–23.722 ln λ = 28.78
N2 = 2,000P < 10–4
(T2 = 500)Highly significant
N1 = 20,000
(T1 = 3,000)
b. Asian data
One epochN1 = 10,0008.00–74.26
Two epochN2 = 10,0008.63–31.952 ln λ = 84.62
N1 = 50,000P < 10–4
(T1 = 2,000)Highly significant
Three epochN3 = 10,0008.24–26.392 ln λ = 11.12
N2 = 3,000P = 0.0039
(T2 = 600)Significant
N1 = 25,000
(T1 = 3,200)
c. African-American data
One epochN1 = 10,0008.00–197.86
Two epochN2 = 10,0009.20–28.692 ln λ = 338.34
N1 = 18,000P < 10–4
(T1 = 7,500)Highly significant
Three epochN3 = 10,00010.29–26.722 ln λ = 3.94
N2 = 16,000P = 0.1395
(T2 = 15,000)Not significant
N1 = 26,000
(T1 = 2,400)