TABLE 2

Essential notation used in analytical model

nNo. of nonmutator cells
m(t)No. of mutator cells at time t
N(t)No. of nonmutators with beneficial mutation at time t
M(t)No. of mutators with beneficial mutation at time t
m0No. of mutator cells at the beginning of a time cycle
μnMutation rate of nonmutators per cell division
μmMutation rate of mutators per cell division
gStrength of mutator (μmn)
WTime until appearance of beneficial mutant from nonmutator subpopulation
XTime until appearance of beneficial mutant from mutator subpopulation
bGrowth rate of cells with beneficial mutation
sCost of being a mutator
t*Time at the end of a cycle (at completion of selective sweep)
Average length of a cycle
λmRate of appearance of beneficial mutation in mutator
λnRate of appearance of beneficial mutation in nonmutator
Time from appearance of an evolved mutator that breaks even until the end of cycle
RLog gain made by mutator at the end of cycle