TABLE 1

MIC for ceftazidime of the TEM-1 and SHV-1 β-lactamase variants

SHV MICsTEM MICs
CAZ (μg/ml)CTX (μg/ml)MutationCAZ (μg/ml)CTX (μg/ml)
1.0–1.50.016R164A0.50–0.750.047–0.064
1.0–1.50.032–0.047R164G0.38–0.50.75–1.0
0.75–1.00.047R164I0.125–0.190.047–0.064
4.0–6.00.064R164L0.1250.016–0.032
0.38–0.50.023–0.032R164P0.094–0.1250.032–0.047
0.5–0.750.075–1.0R164V0.750.032–0.047
0.75–1.00.032R164C0.50.032
1.50.064–0.094R164M8.0–12.00.75–1.0
3.0–4.00.047R164S12.00.094
12.0–16.00.064R164T0.750.032–0.047
1.5–2.00.032R164N16.0–24.00.25–0.38
3.00.064R164Q1.00.047
3.00.094R164H6.00.064–0.094
1.0–1.50.032–0.064R164K1.00.032–0.047
0.190.047–0.064R164R (wt)0.190.023–0.032
8.00.064–0.094R164D1.5–2.00.032–0.047
4.00.094R164E1.00.047
0.25–0.380.19R164F2.00.064–0.094
0.1250.032R164W0.380.032
1.50.023R164Y0.190.047
4.00.094D179G4.00.047