TABLE 4

The expectation and coefficient of variation for Rh for a model with 5 or 10 hypermutable sites in the region (for details see text) and an otherwise uniform mutation rate of 10, with ρ = 0 or 10

No.
hypermutable
Subset size
ρStatistic23512
05E (Rh)1.37 (0.00)1.51 (0.00)1.53 (0.00)1.53 (0.00)
Coeff. var.1.07 (0.00)1.10 (0.00)1.11 (0.00)1.11 (0.00)
10E (Rh)2.43 (0.00)2.70 (0.00)2.77 (0.00)2.77 (0.00)
Coeff. var.0.80 (0.00)0.82 (0.00)0.82 (0.00)0.82 (0.00)
105E (Rh)5.30 (4.64)6.92 (6.12)8.21 (7.33)8.38 (7.49)
Coeff. var.0.39 (0.38)0.37 (0.37)0.36 (0.35)0.35 (0.35)
10E (Rh)6.14 (4.89)7.93 (6.44)9.28 (7.67)9.46 (7.81)
Coeff. var.0.39 (0.37)0.37 (0.36)0.36 (0.35)0.35 (0.35)
  • The sample size is fixed at 50 and the ancestral type is assumed known at each locus. The columns again correspond to different subset parameters for the bound; thus the first column actually refers to Rm; for the other columns, a maximal subset width of 12 was used. For each parameter set, 10,000 simulated samples were created and the estimates for the different widths are all based on this same data set. The term in parentheses in each column gives the estimated number under an infinite-sites model with the same recombination rate and the same overall mutation rate (including the contribution from the hypermutable sites).