TABLE 3

Functional classification of SFPs

Functional categorySFPsProbesRatio
Cell wall (2 ORFs)331
Other transport facilitators (1 ORF)13160.81
Ion transporters (2 ORFs)13320.41
Electron transport and membrane-associated energy conservation (2 ORFs)5320.16
Endoplasmic reticulum (4 ORFs)10630.16
Cytoplasm (7 ORFs)201320.15
Fermentation (33 ORFs)644640.14
Degradation of foreign (exogenous) compounds (9 ORFs)181440.13
Extracellular/secretion proteins (19 ORFs)362950.12
Nucleus (11 ORFs)221910.12
Secondary metabolism (5 ORFs)9800.11
Other cell division and DNA synthesis activities (16 ORFs)272560.11
Protein folding and stabilization (59 ORFs)1059470.11
Other protein fate-related activities (8 ORFs)141280.11
Detoxification (102 ORFs)16915470.11
Cell wall (39 ORFs)585050.11
Mitochondrion (6 ORFs)11960.11
Metabolism of energy reserves (glycogen, trehalose; 37 ORFs)535390.10
Cell differentiation (6 ORFs)10960.10
Metabolism of vitamins, cofactors, and prosthetic groups (84 ORFs)11813250.09
Oxidation of fatty acids (7 ORFs)101120.09
Other protein-synthesis activities (16 ORFs)202190.09
Nonvesicular cellular import (100 ORFs)13614720.09
Intracellular signalling (134 ORFs)19621960.09
Stress response (175 ORFs)22325870.09
Ionic homeostasis (117 ORFs)16418070.09
Cytoskeleton (2 ORFs)3320.09
Nitrogen and sulfur metabolism (74 ORFs)8911350.08
Nucleotide metabolism (144 ORFs)17322330.08
Phosphate metabolism (33 ORFs)384650.08
C-compound and carbohydrate metabolism (415 ORFs)52562390.08
Lipid, fatty-acid and isoprenoid metabolism (214 ORFs)28134740.08
Tricarboxylic-acid pathway (citrate cycle, Krebs cycle, TCA cycle; 25 ORFs)324000.08
Respiration (88 ORFs)11113280.08
DNA processing (76 ORFs)9912300.08
Cell cycle (11 ORFs)141760.08
mRNA transcription (579 ORFs)70290170.08
RNA transport (27 ORFs)344480.08
Other transcription activities (57 ORFs)749080.08
Protein targeting, sorting, and translocation (144 ORFs)17722880.08
Assembly of protein complexes (95 ORFs)11615400.08
Nuclear transport (59 ORFs)769640.08
Mitochondrial transport (80 ORFs)9912440.08
Other cell rescue activities (9 ORFs)121570.08
Plasma membrane (144 ORFs)17421630.08
Cytoskeleton (106 ORFs)13616940.08
Intracellular transport vesicles (41 ORFs)506520.08
Nucleus (755 ORFs)930120800.08
Endosome (12 ORFs)151920.08
Amino acid metabolism (204 ORFs)22632100.07
Glyoxylate cycle (6 ORFs)7960.07
Translational control (31 ORFs)344960.07
Aminoacyl-tRNA-synthetases (37 ORFs)415910.07
Protein modification (187 ORFs)22030160.07
Proteolytic degradation (160 ORFs)18025720.07
Vacuolar transport (56 ORFs)578640.07
Extracellular transport, exocytosis, and secretion (39 ORFs)406050.07
Cytoskeleton-dependent transport (27 ORFs)304320.07
Other intracellular transport activities (32 ORFs)365120.07
Endoplasmic reticulum (153 ORFs)16824570.07
Golgi (80 ORFs)9412720.07
Mitochondrion (360 ORFs)38555800.07
Vacuole or lysosome (59 ORFs)699280.07
rRNA transcription (109 ORFs)11317730.06
tRNA transcription (83 ORFs)8413580.06
Vesicular transport (Golgi network, etc.; 129 ORFs)12621060.06
Peroxisomal transport (16 ORFs)142540.06
Cytoplasm (547 ORFs)45381720.06
Peroxisome (37 ORFs)375900.06
Prokaryotic cell membrane (inner membrane of gram-; 1 ORF)1160.06
Other control of cellular organization (8 ORFs)81280.06
Plasma membrane (1 ORF)1160.06
Centrosome (1 ORF)1160.06
Target of regulation (1 ORF)1160.06
Pentose-phosphate pathway (9 ORFs)71440.05
Translation (64 ORFs)449730.05
Centrosome (30 ORFs)264800.05
Glycolysis and gluconeogenesis (35 ORFs)214780.04
Other energy generation activities (16 ORFs)102560.04
Ribosome biogenesis (215 ORFs)13430470.04
Cell growth/morphogenesis (3 ORFs)2480.04
Golgi (2 ORFs)1320.03
Intracellular transport vesicles (1 ORF)320
Peroxisome (1 ORF)160
Transport mechanism (1 ORF)160
  • Functional classifications were downloaded from http://mips.gsf.de/proj/yeast/CYGD/db/index.html (Mewes et al. 1999) on 11/31/01. Some genes may be found in multiple functional categories.