TABLE 2

Results of genetic screens and tests

Screen withSynthetic lethal
mutation in
No. of
isolates
spt16-11HIR17
HIR2/SPT15
HIR3/HPC17
HPC27
hir1PAF11
Tests withPhenotype of double mutant
hpc2paf1Lethal
hpc2cdc73Slow growth
hpc2hpr1No effect
asf1paf1Lethal
asf1cdc73Slow growth
asf1spt16-11MPT decreased 5°
asf1pob3-7MPT decreased >2°