TABLE 4

Potential candidate genes for QTL interacting epistatically

QTLPosition
(cM)
Candidate
gene
Gene namePosition
(cM)
PhenotypeReferences
D1Mit1478Htr5b5-Hydroxytryptamine (serotonin) receptor 5B63Anxiety and depressionClement et al. (1996)
D2Mit38072Slc30a4Solute carrier family 30 (zinc transporter), member 469Lethal milkDickie (1969)
D2Mit138DbhDopamine β-hydroxylase15.5Lack of placentophagia/lactation problemsThomas and Palmiter (1997)
D3Mit540CrhCorticotropin-releasing hormone behavior8Abnormal maternalPedersen et al. (1991)
D6Mit120MestMesoderm-specific transcript7.5Lack of placentophagia/poor nestLefebvre et al. (1998)
GhrhrGrowth hormone releasing hormone receptor26Failure to nurse first littersEicher and Beamer (1976)
D7Nds140Herc2Hect [homologous to the E6-AP (UBE3A) carboxyl terminus] domain and RCC1 (CHC1)-like domain (RLD) 227Abnormal maternal behavior Lehman et al. (1998)
D8Mit2544Slc6a2Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 245Complex behavior traitsFritz et al. (1998)
D9Mit428Foxb1b (Mf3)Forkhead box B1b41Lactation problemsLabosky et al. (1997)
D11Mit1566CrhrCorticotropin-releasing hormone receptor62Abnormal maternal behaviorPedersen et al. (1991)
D13Mit11538PrlProlactin14Abnormal maternal behaviorLucas et al. (1998)
D15Mit1522PrlrProlactin receptor4.6Abnormal maternal behaviorLucas et al. (1998)
D18Mit5128CamK2aCalcium/calmodulin-dependent protein kinase IIα33Aggressive behaviorChen et al. (1994)