TABLE 3

The reduction in the mean number of pairwise differences (k/k0) due to Muller's ratchet with two classes of mutations

N = 3000: k/k0 (2 SE)Ub = 0.03: k/k0 theoreticalsb = 0.0275Us = 0.05: D (2 SE)Pow 1 (%)k/k0 (2 SE): Ub = 0
ssTssTsb
a. 0.0030.124 (0.023)0.13644–0.91 (0.21)160.156 (0.019)
b. 0.0050.116 (0.019)0.11057–0.95 (0.17)220.140 (0.020)
c. 0.010.082 (0.018)0.0801156753–0.93 (0.21)250.104 (0.024)
d. 0.0150.086 (0.016)0.0642313858–0.98 (0.24)360.102 (0.017)
e. 0.020.083 (0.018)0.0674944260–0.77 (0.24)210.125 (0.018)
f. 0.030.085 (0.022)0.09345604913–0.93 (0.19)250.193 (0.022)
N = 3000: k/k0 (2 SE)Ub = 0.03: k/k0 theoreticalsb = 0.0275Us = 0.01: D (2 SE)Pow 1 (%)k/k0 (2 SE): Ub = 0
ssTssTsb
g. 0.0030.195 (0.035)0.211402–0.65 (0.23)160.273 (0.036)
h. 0.0050.164 (0.024)0.158656–0.86 (0.23)240.291 (0.045)
i. 0.010.15 (0.032)0.1724313–0.86 (0.24)300.401 (0.056)
j. 0.020.246 (0.039)0.233–0.36 (0.28)140.565 (0.089)
N = 6000: k/k0 (2 SE)Ub = 0.03: k/k0 theoreticalsb = 0.0275Us = 0.05: D (2 SE)Pow 1 (%)k/k0 (2 SE): Ub = 0
ssTssTsb
k. 0.0050.079 (0.018)0.05969–0.86 (0.23)260.081 (0.011)
l. 0.010.060 (0.017)0.04415411657–0.79 (0.21)160.051 (0.013)
m. 0.020.062 (0.014)0.049150815188–0.99 (0.190)260.090 (0.019)
n. 0.030.056 (0.013)0.081–0.65 (0.25)190.171 (0.030)
N = 3000: k/k0 (2 SE)Ub = 0.03: k/k0 theoreticalsb = 0.01Us = 0.03: D (2 SE)Pow 1 (%)k/k0 (2 SE): Ub = 0
ssTssTsb
o. 0.0030.135 (0.021)0.15668480–1.18 (0.16)320.190 (0.030)
p. 0.0050.111 (0.024)0.123101325–1.14 (0.20)300.186 (0.030)

Tsb and Tss are the average time (in generations) between clicks of the ratchet with respect to each type of deleterious mutation. —, no clicks were observed during the runs. Other symbols are as in Table 1. Pow 1 is based on forward simulations with fixed θ = 6. The last column contains the reduction of neutral diversity in the absence of mutations with selection coefficient sb.