TABLE 1

Total cholesterol, VLDL, HDL, LDL, and lesion area for the progenitor strains and the F1 offspring at 16 weeks of age

GenderLesion area (mm2)Total cholesterol (mg/dl)VLDL (mg/dl)LDL (mg/dl)HDL (mg/dl)Weight (g)
C57BL/6J Apoe−/−M100,281 ± 46,933 (5)652 ± 33 (5)411 ± 33 (5)151 ± 25 (5)23.0 ± 4 (5)30 ± 2 (5)
F221,006 ± 24,960 (3)596 ± 114 (5)341 ± 93 (5)204 ± 102 (5)14 ± 2 (5)23 ± 0 (3)
FVB/NCr Apoe−/−M17,445 ± 6,533 (5)**976 ± 99 (5)**747 ± 115 (5)*208 ± 47 (5)*32.0 ± 9.9 (7)30 ± 2 (7)
F10,371 ± 5,551 (6)**821 ± 228 (5)487 ± 92 (6)*258 ± 56 (6)18.7 ± 7.1 (6)27 ± 1 (7)
F1 Apoe−/−M56,046 ± 25,065 (5)895 ± 59 (5)**602 ± 81 (5)**161 ± 21 (5)30 ± 9 (5)40 ± 6 (5)
F98,965 ± 19,805 (3)**797 ± 125 (3)512 ± 56 (3)**154 ± 18 (3)21 ± 6 (3)25 ± 3 (3)
  • Total cholesterol, VLDL, HDL, and LDL levels are expressed as milligrams/deciliter. The lesion quantitation is expressed as the cumulative morphometric analysis of five cross sections, expressed as square micrometers per aortic root per mouse. All data are expressed as mean and standard error. The number of animals used for each analysis is indicated in parentheses. A Student's i-test with two-tail, unequal variance measured significance between any two samples. *P < 0.05; **P < 0.001.