TABLE 2

MapManager QT analysis for the F2s from cross 1

Chromosome markerPhenotype (log transformed)GenderLOD% varianceP valueSignificanceModel with respect to C57BL/6J allele
D1Mit359Total cholesterolM + F3.570.00035SuggestiveAdditive/recessive
D1Mit359Total cholesterolF7.1297.5e-8Highly sig.Additive/recessive
D1Mit359HDLM + F3.670.0002Sig.Additive/recessive
D1Mit359HDLM6.2231.6e-7Highly sig.Additive
D1Mit359LDLM + F2.960.00144SuggestiveAdditive
D1Mit359LDLF6.0259.1e-7Highly sig.Additive
D1MIT359VLDLM + F2.340.00529SuggestiveAdditive/recessive
D1Mit359VLDLF3.4140.00044SuggestiveAdditive/recessive
D1Mit203HDLM2.480.00411SuggestiveDominant
D1Mit78HDLM3.2130.00064SuggestiveRecessive
D1Mit231LesionM + F2.350.00443SuggestiveAdditive/recessive
D4Mit41Total cholesterolM + F2.450.00371SuggestiveAdditive
D4Mit41Total cholesterolF2.8110.00147SuggestiveRecessive
D6Mit10LDLM + F2.240.00589SuggestiveAdditive
D9Mit90LDLM + F2.750.00197SuggestiveDominant
D10Mit80HDLM + F2.650.00264SuggestiveAdditive/dominant
D10MIT133VLDLM + F2.350.00443SuggestiveRecessive
D10Mit49LesionM5.3225.7e-6Sig.Additive
D10Mit213LesionM + F7.8191.7e-8Highly sig.Additive/dominant
D10Mit213LesionM5.1217.8e-6Sig.Dominant
D10Mit214LesionF3.5160.00035SuggestiveAdditive/dominant
D10Mit233VLDLF2.4100.00397SuggestiveRecessive
D14Mit55LesionM2.4100.00417SuggestiveDominant
D14Mit60LesionM + F3.280.00062SuggestiveDominant
D14Mit63LesionM2.590.00495SuggestiveDominant
D14Mit158LesionM2.4100.00420SuggestiveDominant
D16Mit103LesionM + F2.560.00319SuggestiveAdditive/dominant
D17Mit164Total cholesterolM + F2.450.00393SuggestiveAdditive/recessive
D17Mit164LDLM2.590.00326SuggestiveAdditive
D17MIT164VLDLM + F2.650.00223SuggestiveAdditive/recessive
D19Mit120LesionM + F3.270.00135SuggestiveRecessive
D19Mit120LesionM3.8160.00014SuggestiveRecessive
  • The phenotypes analyzed are total cholesterol, HDL, LDL, and VLDL and cross-sectional lesion data and are indicated in the second column. Each data set is log transformed. The first column indicates the chromosome and marker on which the linkage was seen. The fourth column gives the LOD score that was derived by dividing the LRS by 4.6. The fifth column indicates the percentage of the total phenotypic variance detected in the F2 cohort with which each marker showing linkage was associated. The next two columns indicate the statistical significance of the linkage, first as a numerical P value and then verbally. The designation of suggestive, significant, and highly significant is determined by 1000 permutation tests for each data set. The last column indicates the best model for the mode of inheritance, with respect to the C57BL/6J allele. This was determined using the MapManager QT program. If two models, such as recessive and additive, appear equally likely by MapManager QT analysis, it is indicated as additive/recessive. Each analysis was done for the sex-combined, the male-only, and the female-only data. Only suggestive or significant linkages are listed in the table. Sig., significant.