TABLE 1

Mutational spectra

Spontaneous (%)
MutationlacIaebgRbE. coli averageTaqc (%)Nucleoside analogs (%)dMutazymee (%)
AT to GC698317510
GC to AT562440212045
GC to TA1642297<120
GC to CG444009
AT to CG91110754
AT to TA9111034011
  • Values shown are the percentages of base substitutions.

  • a Halliday and Glickman (1991).

  • b Hall (1999).

  • c Shafikhani et al. (1997).

  • d Zaccolo and Gherardi (1999).

  • e GeneMorph PCR mutagenesis kit instruction manual (Stratagene).