TABLE 4

Results of simulation studies

True valueA, h2 = 25%, n = 200B, h2 = 10%, n = 200C, h2 = 10%, n = 200D, h2 = 10%, n = 100
ParameterNo iterationWith iterationAllSignificantAllSignificantAllSignificant
Constant1010.1 (0.04)10.0 (0.03)10.1 (0.05)10.1 (0.06)10.0 (0.09)9.9 (0.10)10.0 (0.10)9.9 (0.14)
eff210.83 (0.018)0.94 (0.015)0.92 (0.017)1.00 (0.017)0.87 (0.041)0.97 (0.036)0.83 (0.041)1.17 (0.059)
eff310.87 (0.020)0.97 (0.020)0.95 (0.024)1.03 (0.025)0.84 (0.059)0.93 (0.058)0.80 (0.055)1.13 (0.082)
eff421.66 (0.040)1.87 (0.028)1.84 (0.034)2.01 (0.036)1.80 (0.035)2.01 (0.036)1.73 (0.036)2.39 (0.045)
eff6−1−0.88 (0.022)−0.96 (0.019)−0.99 (0.015)−1.07 (0.019)−0.84 (0.042)−0.94 (0.044)−0.78 (0.045)−1.08 (0.041)
eff7−1−0.88 (0.014)−0.96 (0.012)−0.96 (0.014)−1.05 (0.015)−0.84 (0.032)−0.93 (0.031)−0.81 (0.035)−1.06 (0.049)
eff8−2−1.74 (0.031)−1.91 (0.025)−1.92 (0.031)−2.08 (0.034)−1.75 (0.067)−1.95 (0.064)−1.71 (0.073)−2.33 (0.091)
Adjusted R225 or 1017.9 (0.57)22.7 (0.44)9.8 (0.14)11.4 (0.10)9.2 (0.25)11.2 (0.15)11.1 (0.31)18.9 (0.14)
rms4 or 124.4 (0.03)4.1 (0.02)12.1 (0.03)11.9 (0.03)12.1 (0.03)12.0 (0.09)11.9 (0.05)11.0 (0.05)
wt4135.2 (4.16)136.6 (4.12)125.3 (3.52)127.6 (3.48)100.8 (2.07)102.8 (2.15)45.7 (0.80)49.2 (1.02)
wt354.7 (2.96)53.7 (2.95)59.2 (2.37)58.4 (2.38)69.0 (1.09)68.6 (1.13)35.2 (0.46)34.6 (0.55)
Positionvaries13.0 (0.28)13.2 (0.19)15.9 (0.24)15.0 (0.24)18.5 (0.55)17.2 (0.55)25.8 (0.46)21.1 (0.72)
Proportion in (5–25 cM)0.950.950.780.820.660.700.470.57
  • The true values of the constant and the QTL effects are the same for all simulations. The true value of the adjusted R2 is 25% for simulation A, 10% otherwise, and the corresponding values of the residual mean square (rms) are 4 and 12. The true QTL location is at 15 cM for simulations A and B and 17 cM for simulations C and D. Wt4 represents the sum of the weights given to the correct QTL genotype for each individual and wt3 represents the sum of the weights given to QTL genotypes that are correct for three-quarters of alleles.