TABLE 2

Breeding results for heterozygote Pax6 mutant outcrosses or inter se crosses

MutationOffspring resulting from the cross
M/+ × +/+M/+ × M/+
+/+M/++/+M/+M/M
Pax62Neu8367133212
Pax63Neu9393243018
Pax64Neu6461564a
Pax65Neu67635137
Pax66Neu13212791311
Pax67Neu5491896a
Pax68Neu221394104
Pax69Neu77573144
Pax610Neu9190351
  • Offspring from outcrosses were classified at weaning by slit lamp biomicroscopy. Embryos from inter se crosses were classified at E15–E17.

  • a Two embryos observed with pronounced optic pits and underlying pigmentation.