TABLE 2

Efficiency of end joining a chromosomal DSB

Relevant genotype% cell survivala
rad52 MRE110.5
rad52 MRE11 + 2μ EXO10.4
rad52 mre11Δ<0.00001
rad52 mre11-H125N0.06
rad52 mre11Δ + 2μ EXO1<0.00001
  • a Percentage survival was measured by the number of colonies formed on galactose plates (HO endonuclease induced) divided by the number of colonies formed on glucose plates (HO repressed).