TABLE 7

His+ reversion rates in diploid strains homozygous or heterozygous for Pol mutations

Polymerase allelesHis+ reversion rate × 10−8 (95% confidence limits)Relative rate
Mismatch repair-proficient strains
+/+0.9 (0.2–1.4)1
pol1-Y869A / pol1-Y869A13 (5.1–20)14
+/pol1-Y869A1.1 (0.7–1.7)1.2
pol2-Y831A / pol2-Y831A1.7 (1.2–5.7)1.9
+/pol2-Y831A1.1 (0.7–1.6)1.2
pol3-Y708A / pol3-Y708A8.5 (5.8–9.4)9.4
+/pol3-Y708A0.7 (0.2–1.1)0.8
Mismatch repair-deficient strains (pms1/pms1)
+/+110 (93–140)1
pol1-Y869A / pol1-Y869A950 (790–1300)8.6
+/pol1-Y869A170 (140–170)1.5
pol2-Y831A / pol2-Y831A820 (750–950)7.5
+/pol2-Y831A400 (270–600)3.6
pol3-Y708A / pol3-Y708A1000 (910–1700)9.1
+/pol3-Y708A83 (66–120)0.8
  • Mutation rates are median for 9–18 cultures.