TABLE 3

Fit of a deleterious mutation model to the excess of amino acid SNPs

ParametersFitMutations
h 2Ns<5%5–15% f 1 HoHe
0.5–204470.2927972
–504920.466624
0.01–10041100.21331139
–2004470.2518906
–5004830.338692
–10005010.425579
0.5–300a4640.8040847
Conservative5101329

h, dominance coefficient; 2Ns, the scaled selection coefficient where s is the selection coefficient and N is the effective population size; <5% and 5–15%, the number of deleterious mutations the model predicts at low and moderate frequency, respectively; f1, the estimated proportion of amino acid mutations that are slightly deleterious; Ho and He, the estimated number of sites homozygous and heterozygous, respectively, for a deleterious mutation in an individual.

  • a The average strength of selection when s is exponentially distributed.