TABLE 2

Conservative estimates of the number of deleterious SNPs in an individual's genome

DataD (sample)TD (genome)D/T (%)
SNP-I0.8926.623293.4
SNP-IIa0.8936.175132.5
SNP-IIb1.0936.176273.0

D is the number ofdeleterious SNPs carried byan individual in the genes surveyed and is calculated as the excess ofamino acid SNPs in the sample divided by the number of individuals sampled. T is total number of amino acid SNPs carried by an individual in the genes surveyed (Cargill et al. 1999; Halushka et al. 1999).

  • a The excess is calculated from frequency classes.

  • b The excess is calculated from population classes.