TABLE 5

Incidence of 36Pub-associated skeletal defects

Genotype
+ / +36Pub/9ThW36Pub/2MLPl36Pub/1XMLPc1XMLPc/+36Pub/13Pub13Pub/+36Pub/4CHLc4CHLc/+36Pub/36Pubb36Pub/+b
Total43555103247544
Cleft palatea0/340/40/51/5 (20)0/61/3 (33)03/3 (100)0/44/5 (80) (74)0/32
Basisphenoid incomplete0005 (100)03 (100)02 (50)05 (100) (64)0
Basioccipital rounded0005 (100)03 (100)03 (75)05 (100) (88)3 (7.5)
Axis (C2) malformations0005 (100)03 (100)03 (75)05 (100) (51)3 (7.5)
Fused ribs 6 and 70003 (60)03 (100)02 (50)03 (60) (19)0
Cartilage malformations
    Hyoid0005 (100)03/3 (100)2 (100)3 (75)1 (14)5 (100) (97)3 (7.5) (31)
    Larynx0004 (80)03/3 (100)03 (75)05 (100) (97)2 (5) (8)
    Trachea0004 (80)03/3 (100)02 (50)03 (60) (95)0 (28)
    Neural arches0005 (100)03/3 (100)03 (75)2 (29)5 (100) (97)1 (2.5) (6)
    Digits0005 (100)03/3 (100)03 (75)05 (100) (97)1 (2.5) (0)

Values in parentheses are percentages.

  • a Subset of mice permitting a definitive assessment of palatal development are represented.

  • b Data (percentages only; only cartilage malformations are listed for 36Pub/+ mice) from the previous analysis of 36Pub skeletal defects are provided to the right for comparison (O'Brien et al. 1996).