TABLE 4

Summary of synthetic-lethal interactions

Synthetic-
lethal
with
pho85Δ
Recovered
in Efr
screen
Synthetic ts
phenotype
with pho85-9
ts phenotype
suppressed
by 2μ PCL1
ts phenotype
suppressed
by 2μ PHO80
ts phenotype
suppressed
by other
PCL
plasmids
Synthetic-
lethal
phenotype
with pcl1Δ
pcl2Δ pcl9Δ
Synthetic-
lethal
phenotype
with pcl1Δ pcl2Δ
Synthetic-
lethal
phenotype
with pcl1Δ
Synthetic-
lethal
phenotype
with
pcl2Δ pcl9Δ
Synthetic-
lethal
with cla4Δ
Other results
cln1ΔNoYesYesNoNoYesaNoYesbcln1Δ cln2Δ pho85-9 ts phenotype suppressed by PKC-R398P
cln2Δ
bck1YesYesYesNoNoYesaYesaNoNoReduced mating to far1-c
mpk1ΔNoYesNoNoNoYesaYesaNoNoYests phenotype of mpk1Δ mutant suppressed by PKC-R398P
bem2YesYesYesNoNoYesYesYesNoYesReduced mating to far1-c
cdc42-1NoYesNoMutant phenotype partially suppressed by GPD1::PCL1 and exacerbated by GPD1::PHO80
cla4ΔNoYesYesNo
efr3ΔYesYesNoYesNoNoNoNoNoNo growth defect of efr3Δ pho80Δ strain
spt7YesYesNoNoNoNoNoNoNo
gcr1YesYesNoNoNoNoNoNoNo
srb5YesYesNoNoNoNoNoNoNo
hfi1YesYesNoNoNoNoNoNoNo
  • a Synthetic-lethal phenotype with pcl1D pcl2D is rescued by growth in 1 m sorbitol.

  • b Cvrckova et al. (1995).