TABLE 2

Summary of mutation parameter estimates for wild-type grande lines (WT grande), all 50 grande and petite WT lines, mutator grande lines (M grande), and all 50 M lines

MA linesFluctuation testsVm/VeBateman-MukaiMaximum likelihood
WT grande4.80 × 10-4U = 9.46 × 10-5
sh = 0.217
All WTU ≈ 2.4 × 10-45.87 × 10-3Umin = 2.92 × 10-3U = 1.19 × 10-3
smaxh = 0.102sh = 0.303
M grande1.54 × 10-3Umin = 2.28 × 10-20.005 ≤ U ≤ 0.938
smaxh = 0.0150.049 ≥ sh ≥ 0.0003
All MU ≈ 8.4 × 10-31.47 × 10-3Umin = 1.97 × 10-2
smaxh = 0.018
  • Bateman-Mukai and ML estimates of U have been corrected for selection against deleterious mutations during colony growth using the Kibota and Lynch (1996) function shown in Figure 2, except for the ML estimate for M grandes, where uncertainty in the estimate of s prohibits this correction.