TABLE 1

Mutation rates at three loci in WT (MSH2) and M (msh2) genotypes, estimated by fluctuation tests

GenotypeCAN1CYH2URA3
WT3.2 × 10-78.0 × 10-103.3 × 10-8
(2.2 × 10-7-4.7 × 10-7)(2.6 × 10-10-2.5 × 10-9)(1.4 × 10-8-7.7 × 10-8)
M1.7 × 10-54.1 × 10-94.9 × 10-6
(1.4 × 10-5-2.1 × 10-5)(1.3 × 10-9-1.3 × 10-8)(3.7 × 10-6-6.6 × 10-6)
Relative mutator strength35.15.1151.5
  • The 95% confidence intervals for each genotype at each locus are given in parentheses. Relative mutator strength is the ratio of estimated mutation rate in the mutator genotype to that in the wild type.