TABLE 1

Estimated number of underlying QTL assuming an exponential distribution of effect sizes without dominance

nNF2ndQTL (θ = amin)QTL [θ from (11)]CWZ (C = 1)
10050028.84 {21, 38}46.86 {29.14, 69.87}45.21 {28.06, 67.63}38.40 {32.75, 45.37}
Embedded Image Embedded Image [0%]
10020012.00 {6, 19}57.72 {25.13, 117.19}52.51 {23.65, 104.17}37.43 {30.09, 45.77}
Embedded Image Embedded Image [0%]
205009.65 {5, 14}23.42 {11.85, 42.57}20.98 {10.39, 39.35}19.51 {7.86, 43.90}
Embedded Image Embedded Image [41.0%]
202005.65 {3, 9}25.78 {10.98, 58.69}20.98 {9.02, 48.22}18.10 {10.78, 53.45}
Embedded Image Embedded Image [42.3%]
105006.84 {3, 11}13.99 {5.80, 25.95}11.93 {4.80, 21.27}5.34 {-0.12, 12.61}
Embedded Image Embedded Image [17.7%]
102004.94 {2, 8}17.71 {6.24, 38.67}13.88 {4.74, 32.32}9.63 {6.12, 14.14}
Embedded Image Embedded Image [64.0%]
55004.19 {2, 8}8.84 {3.88, 25.89}6.84 {3.11, 15.62}5.29 {2.77, 8.81}
Embedded Image Embedded Image [48.7%]
52003.85 {2, 7}12.00 {5.12, 29.66}8.68 {3.99, 19.32}5.57 {3.17, 8.05}
Embedded Image Embedded Image [72%]
25002.59 {2, 4}19.38 {3.25, 130}10.65 {2.59, 65}2.66 {1.80, 3.25}
Embedded Image Embedded Image [24.7%]
22002.74 {2, 4}25.05 {3.98, 135.2}13.64 {3.06, 67.58}2.78 {2.01, 3.87}
Embedded Image Embedded Image [47.7%]
2500Cases (147)7.29 {3.25, 13.9}5.21 {2.84, 9.27}
    with nd > 2Embedded Image Embedded Image
2200Cases (177)7.87 {3.97, 22.30}5.53 {3.07, 14.9}
    with nd > 2Embedded Image Embedded Image
  • For each combination of n (the number of underlying loci) and NF2 (the number of F2 individuals scored), 30 different QTL maps were generated, where each map was used in 10 replicate QTL experiments. Each row reports the mean estimate of n over the 300 resulting analyses. The 2.5-97.5% range of estimates is given in braces. In brackets is the percentage of cases where the 95% confidence limits for n included the true value of n. The average value of the power of the QTL studies, τ = (M - θ)/M, is also reported.