TABLE 1

Standard diploid model for mutation-selection balance

Genotype AA Aa aa
Fitness11 – sh1 – s
Frequency in zygote P Q R
Frequency in adult P/w (1 – sh) Q/w(1 – s)R/w

Genotype frequencies add to unity: P + Q + R = 1. The mean zygote fitness is w = 1 – shQsR.