TABLE 3

The effect of variation in mutation rates on the probability of Chud (D. melanogaster)

LocusSimulated > observedUniformStep function
Acp26A0.82170.10100.2416
Acp70A0.84980.01010.0238
Adhs0.30150.30280.3389
Amy-d0.97520.01330.0234
Boss0.59190.24220.2630
Cec-C0.99280.94520.8603
Dpp0.48360.00000.0010
Est60.78620.00100.0060
E(eve)0.98210.86971.0000
G6pd0.95350.00390.0403
Hsp830.32540.03910.1128
In2(L)t0.90200.00910.0164
In3(L)P0.72190.04640.0918
Mlc10.51690.53960.5169
Period0.93080.29700.3265
Pgd0.94250.02000.0663
Ref2p0.26690.03760.0433
Runt0.74380.30590.3359
Sod(−2021)0.98470.12820.1999
Tpi0.91220.55710.5349
Vermilion0.98610.00000.0000
White0.91500.00000.0000
Yp20.83450.00200.0191
Zeste0.32120.18610.6647
  • To measure the extent of spatial heterogeneity in the distribution of segregating sites, we tabulated the length of the longest number of base pairs between any two adjacent polymorphisms in the sample Dmax. For an equal number of segregating sites, greater Dmax indicates more heterogeneity. Listed in the second column is the proportion of the simulated runs with a Dmax > the observed Dmax when rates vary according to Figure 1. For each gene in D. melanogaster, we list the proportion of 10,000 runs with a simulated value of Chud below or equal to the observed one. Column three lists the results when each site is equally likely to mutate (P values in Table 1), column four when mutation rates are variable (see Figure 1).