The probability of hypothetical and published DNA polymorphism surveys under the neutral model
Locus | Sample size | Variable sites | θW | θπ | θH | d | P(BM) | No. of occurrences of each derived variant | P(D) | P(H) |
---|---|---|---|---|---|---|---|---|---|---|
Example | 10 | 1 | 0.35 | 0.20 | 1.80 | 0.010 | 0.004 | [9] | 0.430 | 0.028 |
Example | 10 | 3 | 1.06 | 0.60 | 5.40 | 0.010 | 0.004 | [9 9 9] | 0.128 | 0.002 |
Example | 10 | 3 | 1.06 | 0.60 | 3.62 | 0.010 | 0.004 | [1 9 9] | 0.128 | 0.018 |
Example | 10 | 3 | 1.06 | 0.60 | 1.84 | 0.010 | 0.004 | [1 1 9] | 0.128 | 0.090 |
Example | 10 | 3 | 1.06 | 0.60 | 0.07 | 0.010 | 0.004 | [1 1 1] | 0.128 | 0.665 |
achaete | 147 | 3 | 0.54 | 0.87 | 3.85 | 0.062 | 0.084 | [84, 120, 141] | 0.863 | 0.027 |
asense | 6 | 6 | 2.63 | 2.20 | 4.60 | 0.038 | 0.014 | [1, 1, 1, 4, 5, 5] | 0.215 | 0.077 |
Pgd | 13 | 14 | 4.51 | 5.44 | 6.06 | 0.069 | 0.026 | [1(2), 3(3), 4(3), 5(3), 10(2), 11] | 0.825 | 0.298 |
vermilion | 45 | 6 | 1.37 | 0.81 | 2.55 | 0.022 | 0.008 | [1(3), 3, 24, 44] | 0.160 | 0.070 |
Acp26Aa | 101 | 54 | 10.41 | 8.07 | 17.97 | 0.117 | 0.044 | See Figure 4 | 0.083 | 0.043 |
d is divergence to the outgroup. P(BM) is the probability of a backmutation (materials and methods). P(D) and P(H) are the probability of observing a more negative D and H value under neutrality (α = 0.05, one sided), respectively. Numbers in parentheses indicate the number of sites where the derived variant is observed; i.e., Pgd has two singletons. For Acp26Aa, 4Nc/bp = 0.0725 was used to generate the expected distribution of D and H values. At two of the three polymorphic sites at the achaete locus, the derived variant was inferred to be a loss of a restriction site.