TABLE 1

The effects of interference on sample statistics

4Nes4NerTajima's D: average {% P < 0.05)Fu and Li's D* average (% P < 0.05)Average 4Nes ± SD estimated from codon biasAverage 4Nes ± SD estimated from fixed sitesaAverage 4Nes ± SD estimated from segregating sitesAverage σ2/E2] ± SD
00−0.09 (0.013)0.05 (0.018)0.00 ± 0.060.00 ± 0.070.02 ± 0.230.97 ± 0.85
1−0.09 (0)0.07 (0)0.00 ± 0.060.00 ± 0.070.02 ± 0.231.02 ± 0.36
10−0.51 (0.015)−0.37 (0.025)0.59 ± 0.050.63 ± 0.060.65 ± 0.290.93 ± 0.70
1−0.17 (0)−0.01 (0)0.90 ± 0.070.98 ± 0.080.94 ± 0.261.03 ± 0.38
20−0.62 (0.015)−0.41 (0.010)0.92 ± 0.060.97 ± 0.070.99 ± 0.320.83 ± 0.58
1−0.39 (0)−0.20 (0)1.71 ± 0.081.86 ± 0.091.79 ± 0.330.99 ± 0.30
40−0.99 (0.070)−0.83 (0.025)1.37 ± 0.061.45 ± 0.081.49 ± 0.460.84 ± 0.56
1−0.84 (0)−0.66 (0)3.09 ± 0.143.49 ± 0.193.48 ± 0.530.99 ± 0.34
100−1.48 (0.220)−1.53 (0.085)2.38 ± 0.092.48 ± 0.102.92 ± 0.800.76 ± 0.39
1−1.71 (0.350)−1.70 (0.05)5.32 ± 0.218.26 ± 1.600.98 ± 0.31
200−1.83 (0.615)−2.21 (0.300)3.94 ± 0.184.17 ± 0.246.33 ± 3.710.84 ± 0.38
1−2.13 (0.965)−2.44 (0.435)6.17 ± 0.2415.94 ± 4.261.01 ± 0.31
  • All analyses are based on simulations with 1000 sites, 4Neμ = 0.04, and a sample size of 25 sequences.

  • a For the cases of 4Nes =10 and 20 with 4Ner = 1, samples rarely contain sites fixed for unpreferred codons.