TABLE 1

The consensus groups and associated SLVs of each clonal complex

Clonal complexSequence type of consensus groupNo. of strains in consensus groupSerogroup(s) of strains in consensus groupaSerogroup(s) of SLVsbResistance to penicillincNo. of SLVs differing at a single-nucleotide sitedNo. of SLVs differing at multiple-nucleotide sitesd
NovelSharedNovelShared
laST156169(11), 14(4), 23(1)14(5), 9(4)R2025
lbST162519(3), 9(1), 14(1)9(3), 19(1), [9(2),19(1)] + 1(a)S0006
2aST92514(24), 19(1)14S0223
2bST1521414S1013
3ST124151414S0207
4ST901666R005(4)1
5ST11381818S2023
6ST813523(25), 19(1)23(4), 19(1)R0005(4)
7ST21891212S0104
8ST1801333S0003
9ST53688(1), 11(1)S0101
10ST3732323S0003
11ST199519(4), 15(1)19(1), 14(1)S0002
12ST2421323(12), 19(1)23S0002
13ST247644S1002
14ST1861414R0004(3)
15ST1381266S0200
16ST17322323R102(1)0
17ST6639(2), NK(1)9(1), 14(1)S0011
18aST7741919S0001
18bST17721919S0002
19ST236261919R0001
20ST1912677S0001
21ST20564(5), NT(1)4S1000
22ST7351515S1000
23ST135366R0001
24ST20231919S0001
25ST3021616S0001
26ST21022323S0001
27ST233233S0001
28ST146266S0001
Totals9815(13)66(64)
  • a The numbers of isolates of each serogroup are shown in parentheses. NT, nontypable; NK, not known as the isolate is no longer available.

  • b The numbers of SLVs (not the number of isolates) of each serogroup are shown in parentheses. In one case, a single SLV was represented by multiple isolates of differing serogroups. This SLV, which is associated with consensus group 1b, is represented by three isolates, two of serogroup 19 and one of serogroup 9, and is shown in square brackets. + 1(a), the isolates in the consensus group of clonal complex 1a are also SLVs of the consensus group of clonal complex 1b.

  • c The consensus groups containing penicillin-resistant isolates [minimum inhibitory concentration (MIC) > 0.1 μg/ml] are designated R. Those in which all isolates were penicillin-susceptible are designated S.

  • d The numbers of SLVs corresponding to the four classes—multiple- or single-nucleotide differences, which may be either novel or shared. The numbers of SLVs in parentheses are those after the exclusion of the four highly diverged replacements at ddl. The ST number can be used to find additional information about the isolates from the MLST web site (http://mlst.zoo.ox.ac.uk).