TABLE 1

Summary of nucleotide substitutions for evolved isolates

S1SC1SCS1SCSC1SC2SCS2SCSC2
Days of adaptation11221111111111
New substitutions1528681543
Substitutions per day1.41.20.550.731.40.360.27
Accumulated substitutions15273133242625
  • Isolates are listed as column headings. The first row is the number of days of adaptation for each lineage. The second row is the number of new substitutions for each isolate accumulated from its most recent ancestral isolate; these values include reversions back to previous states. The third row is the per day rate of new substitutions accumulated from the most recent isolate. The fourth row is the total number of accumulated substitutions per isolate that differ from the original starting ancestral isolate A (hence omits reversions back to the original ancestral state).