TABLE 1

Distributions of flux QTL R2 for a 50-enzyme pathway in an F2 population

QTL R2 distribution
cvi and mi distributionsAverage (%)Sum (%)SkewnessPercentage under 2%
i, cvi, = 0.2
i, mi = m (reference)1.9999.5100.0
mi: normal1.9999.34.8667.4
mi: exponential1.9999.321.0276.2
mi: uniform1.9798.47.1289.0
cvi: normal distribution
i, mi = m (reference)1.9698.23.4668.4
mi : normal1.9698.19.2571.8
mi : exponential1.9698.213.6674.1
mi : uniform1.9095.16.9090.6
cvi : gamma distribution
i, mi = m (reference)1.9999.76.9576.2
mi : normal1.9999.78.3078.0
mi : exponential1.9999.79.2177.4
mi : uniform1.9999.47.0790.9
  • The R2 distributions were computed for a 50-enzyme pathway in 100 F2 populations, with four distributions of average activity (m1) reference (same mt for all the QTL), normal, exponential, and uniform; and three distributions of coefficients of genetic variation (cvt), same cvt for all the QTL, normal, and gamma. Mean R2 value of the distribution and average sum of the 50 R2 are in percentage of total flux variance.