TABLE 1

Proportion of noninclusion of the exact parameter value: two mutation rates model

Parameters of the two-rates mutation modelaDemographic parametersTrue valuesAverage estimated valuebSignificance level
m1m2r0.0100.0200.0500.100
2703020 τ 33.726 (1.195)0.0080.0240.0950.203
θ 0 10.812 (1.137)000.0040.061
θ 1 10003777 (7638)000.0020.015
2901050 τ 33.854 (1.493)0.0100.0230.0890.189
θ 0 10.806 (1.051)000.0010.020
θ 1 10003246 (6664)000.0070.019
2703020 τ 99.253 (1.037)0.0030.0050.0150.057
θ 0 10.822 (1.019)0000
θ 1 10004183 (8444)0000
2901050 τ 99.286 (1.072)0.0040.0090.0230.056
θ 0 10.808 (1.019)0000
θ 1 10003986 (8917)0000.001
  • a m1 is the number of slow sites; m2 is the number of fast sites; r is the ratio of mutation rates between the fast and the slow sites.

  • b Average value of the parameters estimated from 1000 coalescent simulations around the true values (standard deviations shown in parentheses).