TABLE 1

trithorax alleles

AlleleHemizygous phenotypeaHeterozygous penetrancebMolecular lesioncReferencesd
trxM17 ts, viable at 22°0.000 (1255)Unknown1
trxZ32 ts, viable at 22°0.000 (799)Unknown1
trx1 Viable, ts ↑ P&E0.008 (1698)~9-kb insert in region encoding first intron2, 3
trxE3 Pupal lethal0.016 (1135)Causes a 271-aa in-frame deletion from aa 21303–7
trxZ16 Pupal lethal0.000 (1017)Causes R to W at aa 1753 in Cys-rich domain1, 8
trxZ11 Pupal lethal0.013 (668)Causes G to S at aa 3601 in SET domain1, 8
trxM18 Pupal lethal0.007 (534)Unknown1, 23
tr XJY16 Larval lethal0.199 (1139)Breakpoint within region encoding aa's 172–2763
trx6.1 Embryonic lethal0.082 (514)Unknown9
trxD Embryonic lethal0.067 (390)Unknown10–16
trxB11 Embryonic lethal0.045 (222)Causes truncated protein after aa 6591, 3, 6, 7, 17
trxA7 Embryonic lethal0.019 (368)Unknown1, 23
trxM14 Embryonic lethal0.015 (334)Unknown1, 23
trxZ15 Embryonic lethal0.102 (422)Unknown1
trxJY25 Embryonic lethal0.155 (161)Unknown, a T(Y;3) not in trxThis study
trx7. 1 Embryonic lethal0.097 (527)Unknown9
trxZ44 Embryonic lethal0.052 (192)Unknown1, 23
trx3 Embryonic lethal0.208 (525)Unknown15, 18, 19
trxJY21 Embryonic lethal0.136 (309)UnknownThis study
Df(3R)redP52 Embryonic lethal0.105 (500)Deletes trx, removes 88A4 to 88B4-51, 3, 12, 18, 20, 21
Df(3R)redP6 Embroynic lethal0.331 (136)Breakpoint in second intron, removes 88B1 to 88B3-C21, 3, 22

The top-to-bottom organization of the alleles reflects their relatively increasing contribution to the penetrance and expressivity of the homeotic transformations examined in this study (see Table 2). The exception to this organization is that trx3 and trxJY21 cause a slightly more transformed phenotype than the two deficiencies that are listed at the bottom for convenient reference.

  • a Phenotypes are for animals heterozygous for the trx mutant chromosome and a Df(3R)redP52 chromosome. ts, temperature sensitive; ts ↑ P&E, increasing penetrance and expressivity with increasing temperature.

  • b Numbers on the left are the frequency of appearance of at least one transformation phenotype in adults heterozygous for the trx mutant chromosome and TM1 or TM6B balancers. Numbers of adults examined are in parentheses.

  • c See Figure 1 for more detailed descriptions.

  • d Numbers refer to the following list: 1, Mortin et al. (1992); 2, Ingham and Whittle (1980); 3, Breen and Harte (1991); 4, Kennison and Tamkun (1988); 5, Mozer and Dawid (1989); 6, Mazo et al. (1990); 7, Sedkov et al. (1994); 8, Stassen et al. (1995); 9, Tripoulas et al. (1994); 10, Lewis (1968); 11, García-Bellido and Capdevila (1978); 12, Capdevila and García-Bellido (1981); 13, Duncan and Lewis (1982); 14, Botas et al. (1982); 15, Ingham (1985a); 16, Capdevila et al. (1986); 17, Kuzin et al. (1994); 18, Ingham (1981); 19, Ingham (1983); 20, Lewis (1981); 21, Parkhurst et al. (1988); 22, Gans et al. (1980); 23, D. B. Bailey and P. J. Harte (unpublished results).