Imprinting (parental) effects in Drosophila

ChromosomeDirection of imprintaReferenceb
In(1)sc8 and Dp(1;f)1187cPaternalProkofyeva-Belgovskaya (1947) Karpen and Spradling (1990)
Dp(1;4)Wm254.58a PaternalSpofford (1959, 1961); Hessler (1961)
In(1)wm2d MaternalHess (1970)
Dp(1;3)wVCO MaternalKhesin and Bashkirov (1978)
In(1)wm4 MaternalKhesin and Bashkirov (1978)
In(3)Uab1 MaternaleKhuhn and Packert (1988)
T(1;2)dorvar7 PaternalDemakova and Belyaeva (1988)
Dp(1;f)LJ9 PaternalThis work
  • a The direction of the imprint is arbitrarily listed as the parent producing offspring with mosaic or inactivated gene expression.

  • b In addition to these examples of genomic imprinting, the term genomic imprinting has also been applied to an apparently permanent change in gene activity (Dorn et al. 1993), a process called epimutation by Holliday (1987), and a nonparental chromatin effect in Drosophila (Bishop and Jackson 1996).

  • c Dp(1;f)1187 is a derivative of In(1)sc8.

  • d In(1)wm2 occurs in D. hydei; all others are found in D. melanogaster.

  • e As the imprinted homeotic transformations associated with Uab1 are likely due to a gain-of-function mutation, the direction of the imprint is defined as maternal, although the mutant phenotype is expressed only when the mutation is transmitted by the male parent.