TABLE 2

Distribution of Leu+ recombinants in the proximal configuration

DeletionsReplacementsTriplications
GenotypeaEventsbRatecEventsbRatecEventsbRatecLeu+ rated
Wild type60 (24)1.240 (16)0.80.0<0.052.0 ± 0.8
rfa1-D228Y 87 (35)2113 (5)3.00.0<0.0524.0 ± 9.0
rad1 38 (15)0.559 (23)0.83 (1)0.041.4 ± 0.5
rad1 rfa1-D228Y 51 (20)1.849 (19)1.70.0<0.093.5 ± 1.0
rad52 95 (56)0.13 (2)0.0032 (1)0.0020.1 ± 0.03
rad52 rfa1-D228Y 100 (60)4.80.0<0.080.0<0.084.8 ± 1.4
rad1 rad52 68 (23)0.00632 (11)0.0030.0<0.00030.009 ± 0.004
rad1 rad52 rfa1-D228Y 90 (36)0.610 (4)0.070.0<0.020.7 ± 0.3
  • a The complete genotypes of the strains are listed in Table 1.

  • b Percentage of Leu+ prototrophs for each genotype. The number within parentheses represents the actual number of Leu+ prototrophs detected.

  • c The rate (× 10–5) is determined from the Leu+ rate multiplied by the percentage of events in each class.

  • d Rates of total Leu+ recombination (× 10–5) are given as the mean ± SD (Jinks-Robertson and Petes 1986).