TABLE 2

Simulations (and predictions in parentheses) based on multiplicative gene action with mutants of equal effect, t, on the heterozygote

C2 × 102NLNe/Nπ/π0s/sd
Deleterious mutations (t = 0.05 when N = 100, otherwise t = 0.02)
4.941001 0.37 (0.41)0.42 (0.45)0.60 (0.65)
3.511000 0.07 (0.11)0.19 (0.19)0.45 (0.52)
0.20a8000 – (0.17)0.16-0.30 (0.21)0.54-0.60 (0.54)
0.20a10,0000 – (0.09)0.09 (0.10)0.39 (0.41)
0.20a1,000,0000 – (0.08)0.08 (0.08)0.21 (0.31)
Favorable mutations (t = 0.14)
3.571,0000 – (0.007)0.023 (0.021)0.30 (0.28)
1.6810,0000 – (0.001)0.004 (0.003)0.17 (0.24)
  • Predictions for the model of deleterious mutations were made using Equations 5, 6, and 10, and those for the model of favorable mutations using Equations 5 and 13, as explained in the text.

  • a Simulations taken from Table 1 of Charlesworth et al. (1995).