TABLE 1

Substitution rates and among-site rate variations of 51 nuclear genes of vertebrates

GenesAccession numbersaAmino acidsCVDbαpcdd
Acetylcholine receptor α subunitP02708; X03986; X07330; X172444561.280.510.410.1580.214
Acetylcholine receptor δ subunitX55019; K02582; K02903; X070695080.830.821.050.3150.455
Acetylcholine receptor γ subunitX01715; X03818; K02904; X070685020.700.811.670.3230.439
α-GlobinV00493; V00714; J00855; X142591420.631.021.930.3190.425
Annexin IIM14043; M14044; X53334; M607683391.210.370.550.1030.120
B-mybX13293; X70472; X67505; M758706240.850.940.930.2680.370
Bcl2-Ig fusion geneX06487; M16506; Z11961; X824611610.501.542.590.2360.284
Beta 2 thyroid hormone receptorX04707; U15542; M65207; M353593681.980.120.210.0490.057
C-kit proto-oncogeneX06182; Y00864; D13225; M807989090.441.773.450.3430.447
C-mybX52125; M12848; M14129; L227416151.010.720.680.1840.237
C-yes proteinM15990; X67677; X13207; X143775351.960.200.200.0920.124
CD18-integrin β-2X64072; X14951; X71768; S493647901.300.420.430.1530.203
CDC2X05360; M38724; X16881; M606802951.500.260.310.0920.112
Complement component 3K02765; K02782; U16848; U1925314930.471.203.290.4440.643
Connexin 43X52947; X62836; M29003; X172433781.690.270.240.0690.083
Cyclin AX68303; Z26580; X72892; X537453650.751.281.140.3070.432
E-cadherinZ13009; X06115; M22180; U047088560.701.091.310.3790.573
Erythroblast virus oncogene homolog 2J04102; J04103; X07202; X526354641.000.730.700.2260.310
Estrogen receptorX99101; M38651; X03805; A409075800.970.600.810.2030.263
Focal adhesionL13616; M95408; M86656; U1107810512.000.200.170.0870.119
FollistatinP19883; Z29532; X87609; P315153151.510.330.330.1080.136
GATA-3-transcription factorX55122; X55123; X56931; M765654301.640.390.240.0720.088
HedgehogL38518; X76290; L28099; L352484081.290.680.360.1640.232
Histon H2A.XX14850; X58069; V00413; M212871392.020.200.190.0850.114
Lactate dehydrogenase-AX02152; U13687; X53828; U071793301.030.650.710.1460.176
Lamin B1L37737; X16705; X16878; X063445771.000.650.820.1990.255
Midkine proteinX55110; M19662; X76482; U060481400.680.921.630.3710.537
MOS proto-oncogeneJ00119; J00620; M19412; X133113280.641.121.690.3840.561
Muscle pyruvate kinaseX56494; D38379; J00903; U038785271.420.280.380.1400.186
Myogenic factor Myf-5X14894; X56182; X73250; X567382550.900.880.790.3140.482
N-cadherinX54315; M31131; X07277; X576758991.370.460.380.1370.179
N-mycY00664; X03919; D90071; X586704040.940.820.770.3120.482
Na+/K+ ATPase β-1-subunitM25160; X16646; J02787; U170613010.900.780.860.2860.412
Na+/K+ ATPase β-2-subunitM81181; X16645; L13208; M377882730.621.112.080.4870.787
NAD(+) ADP-ribosyltransferaseP09874; P11103; P26446; P316699911.000.550.770.2180.290
Nerve growth factorX52599; M14805; X04003; X557162300.800.900.990.3570.555
Neural cell adhesion moleculeX16841; Y00051; M15860; M256967131.100.650.590.1380.168
Neurotrophin-3M37763; M53257; M83378; Z300902280.431.512.450.1100.119
Nucleolar protein N038M28699; M33212; X17200; X560392820.790.861.260.3010.415
NucleolinM60858; X07699; X17199; X729575940.600.952.230.3700.514
Ornithine decarboxylaseP11926; P00680; X64710; X563164481.220.430.470.1740.236
P53 cellular tumor antigenX02469; X00741; X13057; M369623430.531.241.810.4360.672
Prohormone convertaseX17094; X54056; Z68093; M804715901.340.450.400.1370.179
RhodopsinU49742; M55171; D00702; S798403481.280.320.440.1350.172
S6 II kinaseL07597; M28489; M28488; M201877181.800.320.220.0790.101
SPARCJ03040; X04017; L24906; X624832961.270.500.420.1510.199
TGF β-2M19154; X57413; M31154; X518174091.700.310.220.1170.168
TGF β-3X14149; M32745; X58071; X518173890.730.991.040.1230.140
Transcription factor Eryf1X17254; X15763; M26209; M765662680.621.231.950.4520.703
Tyrosine phosphataseX53364; M36033; L22437; U091357911.500.510.270.1730.275
VimentinZ19554; X51438; M15850; X168434511.350.430.380.1110.138
  • a The Gen Bank/EMBL/SwissProt accession numbers are presented in the order of human, mouse, chicken, and frog sequences.

  • b Average number of substitutions per site along the tree.

  • c Proportional differences between the mouse and chicken proteins.

  • d Gamma distances between the mouse and chicken proteins.