TABLE 1

Parameters used in describing the mutation process

ParameterDefinition
Abbreviations
bBase or base pair
kbKilobase or kilobase pair
Parameters
CThe variously calculated ratio of total mutations to observed mutations
fMutant fraction in a population
GGenome size in bases or base pairs (haploid unless otherwise indicated)
GeEffective genome size (portion in which most mutations are deleterious)
hDominance coefficient associated with a typical detrimental mutation
ΔMRate of decline per generation of the mean of a quantitative fitness trait
NPopulation size
Embedded Image Mean reduction in trait value of a single mutation when homozygous
Embedded Image Mean selection coefficient against a heterozygous deleterious mutation
URate of deleterious mutations per genome per sexual generation
UcU for a chromosome
UdU for the diploid genome
UhU for the haploid genome
ΔVIncrease in variance of a quantitative fitness trait in parallel lines
δReduction in mean fitness of inbred versus randomly mated diploids
μbMutation rate per base pair per replication
μgMutation rate per genome per replication
μegMutation rate per effective genome per replication
μegsMutation rate per effective genome per sexual generation
μlinMutation rate under conditions of linear replication in RNA viruses
μbinMutation rate under conditions of binary replication in RNA viruses
μmlin + μbin)/2 for RNA viruses