Biased repair of palindromic loop mismatches

Percent palindrome retention(n)b
Loop aloneLoop + SBMMs
StrainaCross 1ACross 1BCross 2ACross 2B
K1c65 (51)63 (27)50 (38)53 (32)
MTCHO+62 (34)52 (29)
Clone B56 (32)55 (29)
  • a K1c and MTCHO+ are mismatch repair proficient; clone B is mismatch repair deficient.

  • b Percentage of products that retained palindrome; number of products tested given in parentheses; SBMMs, single-base mismatches.