TABLE 6

Summary of variation at nonsynonymous (NS) and synonymous (S) sites within and between different species

Fixed (between)Polymorphic (within)
SpeciesLocusNSSNS/SNSSNS/S
DrosophilaND5a15540.287110.64
cyt bb10970.106120.50
MouseND3c2230.0911130.85
ChimpanzeeND2d11840.137320.22
ND3e4310.13431.33
HumanND2d11840.1310110.91
ND3e4310.13470.57
  • In all cases, the ratio of nonsynonymous to synonymous polymophisms within species is greater than the ratio for fixed differences between species. The tests are not significant for ND5 in Drosophila, ND2 in chimpanzees, and ND3 in humans.

  • a Rand et al. (1994).

  • b Ballard and Kreitman (1994).

  • c Nachman et al. (1994).

  • d This study. The chimpanzee data is from the west African subspecies P. t. verus.

  • e Nachman et al. (1996).