TABLE 1

Enhancers and suppressors of GMR-sina

No. of allelesMap positionsina4 interactionClonal phenotype
Enhancer groups
ES1-11110F7-11A71.5Occasional missing R cells
ES2-12651C-52F0.8Wild-type
ES2-21539B1-21.0Wild-type
ES2-3 Sin3A249B3-63.1Very small clones or scars
ES2-4 Star621E1-23.4n.d.
ES3-1584B1-20.6n.d.
Suppressor groups
SS2-14023C1-21.1Small rhabdomeres
SS3-1284B1-2n.d.n.d.
SS3-2 glass1191A1-22.4n.d.
SS3-3 UbcD11488D5-60.9Missing R cells; scars
SS3-4 SR3-4a2476D3-E1.2Very small clones or scars
SS3-5272C1-73A3n.d.n.d.
SS3-6864C5-E12.0Fallen rhabdomeres
SS3-7267C4-52.0Fallen rhabdomeres
  • n.d., not determined.

  • Six enhancer and eight suppressor groups were identified by lethal complementation. Not shown in the table are 73 mutants that complement all groups. Map positions were initially defined by meiotic recombination analysis of the modifier phenotype, and subsequently refined by lethal complementation tests using deficiencies and P element lines. Alleles of ES3-1 and SS3-1 mapped to the same location and failed to complement for recessive lethality, and thus are likely opposing alleles of the same locus. Modification of the sina4 phenotype was scored in eye sections from flies heterozygous for a given modifier mutant, and homozygous for sina4 (see materials and methods for details). Interaction strength was calculated as the ratio of percent R7 ommatidia in Modifier/+; sina4 eyes over percent R7 ommatidia in sina4 eyes. Values between 0.8 and 1.2 represent insignificant interaction. glass-sina4 data is from Carthew et al. 1994.