RT Journal Article
SR Electronic
T1 THE INBREEDING EFFECTIVE POPULATION NUMBER AND THE EXPECTED HOMOZYGOSITY FOR AN *X*-LINKED LOCUS
JF Genetics
JO Genetics
FD Genetics Society of America
SP 731
OP 737
VO 97
IS 3-4
A1 Nagylaki, Thomas
YR 1981
UL http://www.genetics.org/content/97/3-4/731.abstract
AB Assuming random mating and discrete nonoverlapping generations, the inbreeding effective population number, N(i)e, is calculated for an X-linked locus. For large populations, the result agrees with the variance effective population number. As an application, the maintenance of genetic variability by the joint action of mutation and random drift is investigated. It is shown that, if every allele mutates at rate u to new types, then the probabilities of identity in state (and hence the expected homozygosity of females) converge to the approximate value (1 + 4N(i)eu)-1 at the approximate asymptotic rate exp{—[2u + (2N(i)e)-1]t}.