TY - JOUR
T1 - A Fundamental Relationship Between Genotype Frequencies and Fitnesses
JF - Genetics
JO - Genetics
SP - 1087
LP - 1093
DO - 10.1534/genetics.108.093518
VL - 180
IS - 2
AU - Lachance, Joseph
Y1 - 2008/10/01
UR - http://www.genetics.org/content/180/2/1087.abstract
N2 - The set of possible postselection genotype frequencies in an infinite, randomly mating population is found. Geometric mean heterozygote frequency divided by geometric mean homozygote frequency equals two times the geometric mean heterozygote fitness divided by geometric mean homozygote fitness. The ratio of genotype frequencies provides a measure of genetic variation that is independent of allele frequencies. When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes.
ER -