PT - JOURNAL ARTICLE
AU - Lachance, Joseph
TI - A Fundamental Relationship Between Genotype Frequencies and Fitnesses
AID - 10.1534/genetics.108.093518
DP - 2008 Oct 01
TA - Genetics
PG - 1087--1093
VI - 180
IP - 2
4099 - http://www.genetics.org/content/180/2/1087.short
4100 - http://www.genetics.org/content/180/2/1087.full
SO - Genetics2008 Oct 01; 180
AB - The set of possible postselection genotype frequencies in an infinite, randomly mating population is found. Geometric mean heterozygote frequency divided by geometric mean homozygote frequency equals two times the geometric mean heterozygote fitness divided by geometric mean homozygote fitness. The ratio of genotype frequencies provides a measure of genetic variation that is independent of allele frequencies. When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes.