PT - JOURNAL ARTICLE
AU - Padhukasahasram, Badri
AU - Marjoram, Paul
AU - Wall, Jeffrey D.
AU - Bustamante, Carlos D.
AU - Nordborg, Magnus
TI - Exploring Population Genetic Models With Recombination Using Efficient Forward-Time Simulations
AID - 10.1534/genetics.107.085332
DP - 2008 Apr 01
TA - Genetics
PG - 2417--2427
VI - 178
IP - 4
4099 - http://www.genetics.org/content/178/4/2417.short
4100 - http://www.genetics.org/content/178/4/2417.full
SO - Genetics2008 Apr 01; 178
AB - We present an exact forward-in-time algorithm that can efficiently simulate the evolution of a finite population under the Wright–Fisher model. We used simulations based on this algorithm to verify the accuracy of the ancestral recombination graph approximation by comparing it to the exact Wright–Fisher scenario. We find that the recombination graph is generally a very good approximation for models with complete outcrossing, whereas, for models with self-fertilization, the approximation becomes slightly inexact for some combinations of selfing and recombination parameters.